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Bone Injections Reduce Infection and Pain in TKA Patients
Studies show promising results for IO instead of IV antibiotics and morphine.
Publish Date: November 3, 2022   |  Tags:   Breaking News
Bone Injections
NEW PROTOCOL Two recent studies show promise that intraosseous injections can help prevent infections and decrease post-op pain after TKAs.

A study has found that injecting an antibiotic directly into the bone of knee replacement patients was more effective at lowering infections than intravenous administration of the same drug.

A paper on the 2021 study that won the Chitranjan S. Ranawat Award and appeared in The Bone & Joint Journal showed that, of the 1,060 patients who underwent knee replacement between May 2016 and July 2020, eight of the 572 who received IV vancomycin experienced a periprosthetic joint infection, compared to only one of the 488 patients who got the same antibiotic intraosseously.

“While the study suffers from limitations of a retrospective, multi-surgeon investigation, early findings are encouraging,” states the study. “IO delivery of vancomycin after tourniquet inflation is a safe and effective alternative to IV administration, eliminating the logistical challenges of timely dosing.”

A subsequent related study by the same authors published in the Journal of Arthroplasty showed that IO morphine added to the vancomycin injection was effective in decreasing post-op pain for total knee arthroplasty patients. Twenty-four patients were administered the antibiotic alone and 24 were given the antibiotic-morphine mix. The latter group reported lower pain scores and consumed less opioids for the first two weeks after their surgeries.

“IO morphine combined with a standard antibiotic solution demonstrates superior postoperative pain relief immediately and up to 2 weeks,” states the study. “IO morphine is a safe and effective method to lessen postoperative pain in TKA patients.”

Adam Taylor