The Lowdown on Low-Flow Anesthesia

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Minimizing volatile anesthetic delivery maximizes its benefits.


low-flow anesthesia GENERAL DISREGARD Low-flow anesthesia is a beneficial but underused practice.

Low-flow anesthesia has been around for decades, but budget-conscious facilities are more interested than ever in the technique that limits waste of costly inhalational anesthetic agents while improving patient care and staff safety. Let's explore those benefits further.

1. Cost savings
Where is low-flow use most widespread? In third-world countries where the high cost of volatile agents desflurane and sevoflurane demand cost-savings measures wherever possible. The expense of volatile anesthetics directly affects your anesthesia budget — if your providers dropped flow rates from 2L per minute to 500cc per minute, for example, you'd realize several thousand dollars a year in savings per OR — so convince your providers to limit flows of the costliest agents. Isoflurane is inexpensive, so the potential cost savings of using it during low-flow anesthesia is nominal. If your providers use sevoflurane or desflurane, however, the cost savings can add up.

2. Less waste
The higher the flow of air and oxygen through your anesthesia machine, the more volatile agent the flow picks up and potentially releases into the atmosphere. The negative impact of waste anesthetic gases on the atmosphere is very small, but very real, and something you need to be conscious of limiting.

Perhaps a more immediate and tangible danger hits closer to home: Waste anesthesia gas also contaminates the OR and could harm your surgical team members, a potential danger regulated by OSHA. No worker should be exposed to a concentration of waste anesthetic gases >2 parts per million (ppm) of any halogenated anesthetic agent, according to OSHA recommendations. When such agents are used in combination with nitrous oxide, levels of 0.5 ppm are achievable. Nitrous oxide, when used as the sole anesthetic agent, should be controlled so that no worker is exposed at 8-hour time-weighted average concentrations of >25 ppm during anesthetic administration, advises OSHA.

GRADUAL DROP
How Low Can You Go?

Most anesthesia providers use 2L to 5L of fresh gas flow per minute. Why aren't more dialing back during the maintenance phase of anesthesia when lower fresh gas flow is needed to meet a patient's demand for oxygen and anesthetic? In my estimation, less than 10% of providers are using low-flow techniques because it's not yet ingrained in the culture of anesthesia.

The accepted parameters of low-flow have changed over the years, dropping gradually from 2L per minute to 1L per minute in the late 1990s, due in large part to the increased awareness of the greenhouse effect anesthetic gases have on the atmosphere. Now, if you have a closed breathing circuit with a good absorber or even an LMA — you can deliver low-flow anesthesia without an endotracheal tube — with an excellent seal, you can drop down to 300cc (0.3L) per minute, although many pro-viders consider 500cc (0.5L) per minute to be an adequate (and safe) low-flow rate.

The low threshold is partially based on the patient's oxygen requirement, as individuals of average size and weight need no more than 300cc of oxygen per minute to survive.

— Ashish C. Sinha, MD, PhD

3. Better patient care
Low-flow anesthesia helps limit the risks of hypothermia and surgical site infections by letting you better maintain a patient's core temperature and humidity level.

During the normal breathing process, the air that enters the 23 levels of division in the lungs is heated and humidified. The temperature and humidity of breathed-in air aren't neutralized until the air reaches the 4th level. Sending cold, dry volatile anesthetics into the lungs makes that neutralization more difficult, which lowers a patient's core temperature and humidity level.

When humidity levels drop, the normal functioning of the lungs' mucus membranes is reduced, which inhibits breathing and could lead to mucus plugs and ventilation difficulties.

Volatile anesthetics can exacerbate hypothermia issues for patients already lying in cold ORs, without clothes, with large body surfaces uncovered and with internal organs potentially exposed. They're being injected with fluids that in most cases aren't heated to body temperature and, because they're sedated, can't shiver to generate muscle heat. All these factors combine to drop core temperatures, which can cause clotting issues, treatment-resistant heart arrhythmia and increased surgical site infection risks.

Machine advances
Newer anesthesia machines are designed to facilitate the delivery of low-flow anesthesia. When shopping for a new machine, its capacity for low gas flow is an important feature to consider. Some machines have default low-flow settings, so be sure the machines' capabilities match the goals of your providers. Machines that can deliver low-flow rates typically have advanced breathing circuits and absorbers, and more accurate electronic flowmeters that let providers deliver lower flows of anesthetic gases much more accurately than they could with mechanical components found on older models.

COUNTERPOINT
Is Low-Flow Worth It?

Can low-flow techniques really help control anesthesia-related expenses and improve case outcomes? George Mychaskiw II, DO, professor of anesthesiology at the University of Central Florida College of Medicine, isn't so sure.

He says there's "no doubt" low-flow techniques result in lower anesthetic costs, but questions how much savings are truly realized. He claims an entire year of low-flow anesthesia results in annual savings of "only" $3,000 per OR.

"Enhanced anesthesia system technology, better vaporizers, and inhaled anesthetics of lower solubility now permit anesthetists to deliver low and minimal flows with an acceptable margin of safety, so it logically follows that all anesthesia should be conducted at low and minimal flow," he writes in the October-December 2012 issue of the Journal of Anesthesiology Clinical Pharmacology.

Dr. Mychaskiw, however, points to a lack of clinical evidence that proves the beneficial impact of low-flow anesthesia on core body temperature or airway moisture. He does concede that it's unlikely the humidification of fresh gas flows is a bad thing, so he considers low-flow "a reasonable, albeit not well-supported, practice."

— Daniel Cook

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