Standardized Scripts for Every Surgery

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Tailoring pill counts to procedure type will right-size your post-op opioid prescriptions.


MORE WITH LESS The nation's crisis has caused providers and facilities to figure out how to manage pain with far fewer opioids.

Why should a breast biopsy patient receive the same amount of opioids as someone who’s had both knees replaced? That one-size-fits-all approach to pain management has contributed to the nation’s current opioid crisis — surgeons have been flying blind, often writing oversized scripts based on habit or opinion. What if your physicians had a guideline for how many opioids to prescribe for a particular procedure? Many say proscriptive prescribing would limit the number of unused and unneeded pills that continue to fuel the epidemic.

A prominent leader in that charge is Chad Brummett, MD, co-director of the Michigan Opioid Prescribing Engagement Network (OPEN), a program launched in 2016 with support from the Michigan Department of Health and Human Services, Blue Cross Blue Shield of Michigan Value Partnerships and the Institute for Healthcare Policy and Innovation at University of Michigan. Michigan OPEN’s goal is to standardize post-op and acute care opioid prescribing.

The research group rose out of a desire to cover up a blind spot in the CDC’s 2016 opioid prescription guidelines, which were released in response to the epidemic of overdose deaths. “I’m a big fan of the guidelines, but they’re really about chronic pain and chronic pain management,” says Dr. Brummett. “They have one line for acute pain that simply says to prescribe for the lowest amount possible for the shortest time possible. While I agree with that recommendation, it doesn’t necessarily direct surgeons on how to prescribe.”

Michigan OPEN has released evidence-based opioid prescription guidelines for 25 surgeries, and is in the process of adding more (see “Proven Prescribing Recommendations”).

Awareness of the need to right-size opioid prescriptions is growing among surgeons, OR staff, facility leaders and patients, and not a moment too soon. “Becoming a new persistent opioid user is one of the most common complications after elective surgery, and yet it’s something we hadn’t previously thought about or talked about with patients,” says Dr. Brummett.

His team reported in 2017 that roughly 6% of surgical patients who presented as opioid-naïve became new persistent users. The research covered both outpatient and inpatient surgeries and, interestingly, the intensity of the procedure didn’t matter; the percentage stayed about the same.

An important reason for standardizing opioid prescriptions is to eliminate confusion and even subconscious behavior by patients. “There’s some psychology behind it, in terms of, ‘If we give you more, you’re going to take more,’” says Charles Hannon, MD, a resident physician in the department of orthopedic surgery at Rush University Medical Center in Chicago, Ill. Dr. Hannon says Rush’s clinical trials found that hip and knee replacement patients who received 90 opioid pills were more likely to take more pills than patients who received 30.

Check out these numbers that emerged from the trials. The average number of opioid pills Rush hip and knee surgeons typically prescribed was between 90 to 120, in line with the national average. Dr. Bannon reports that the median number of leftover pills among patients who received 90 pills was 73, while among patients who received 30, it was 15. That means both groups took roughly the same number of pills. “We thought, ‘This is crazy, everyone really should be prescribing much fewer pills than they actually are,” says Dr. Hannon.

EXACT COUNT
Proven Prescribing Recommendations
SAFE SUGGESTION Hip replacement patients should receive up to 30 opioid pills to manage post-op pain, according to Michigan OPEN's evidence-based research.

The Michigan Opioid Prescribing Engage-ment Network (OPEN) has partnered with institutions and physicians throughout the state to identify and disseminate best practices in acute care opioid prescribing. They tracked statewide prescribing rates, new persistent use, refills, consumption, spending and patient utilization, and used the data to create prescribing recommendations for specific surgical procedures, as well as inform policy and develop educational materials for patients and providers. A sample of the program’s 25 prescribing recommendations shown here are the result of Michigan OPEN’s extensive research and evidence-based data. Michigan OPEN says it will revise the recommendations if needed as new data emerges and is in the process of adding more.
Joe Paone

Procedure No. of Oxycodone 5 mg tablets
thyroidectomy 0-5
breast biopsy/lumpectomy 0-5
laparoscopic anti-reflux (Nissen) 0-10
appendectomy (lap or open) 0-10
hernia repair (minor or major) 0-10
sleeve gastrectomy 0-10
laparoscopic cholecystectomy 0-10
prostatectomy 0-10
open cholecystectomy 0-15
colectomy (lap or open) 0-15
hysterectomy 0-15
open small bowel resection 0-20
total hip arthroplasty 0-30
total knee arthroplasty 0-50

Full guidelines available at no cost at michigan-open.org/prescribing-recommendations

Patient satisfaction scores can affect how much a physician gets reimbursed, so of course doctors are sensitive about those scores’ relationship with pain control. The rationale is that if they prescribe fewer, or zero, opioids to the patient, the patient will feel more post-operative pain and be less satisfied with their care. They also want to avoid patients’ request for refills, so they provide more pills than necessary up front, just in case.

Dr. Brummett and his colleagues have found these concerns to be baseless. “Our group and others have shown that there really does not appear to be an association between the number of opioid pills prescribed and patient satisfaction for their care — or their likelihood of refill,” he says.

Individualized regimens

While much work has been put into standardizing prescriptions based on procedure type, there’s a complementary factor that still needs work: tailoring opioid prescriptions not only to procedures, but also to individual patients. “We need to learn a little bit more about which patients are going to require more pills than others,” says Dr. Hannon.

Becoming a new persistent opioid user is one of the most common complications after elective surgery.
— Chad Brummett, MD

Standardizing prescriptions by procedure type makes things a lot easier from an administrative point of view, but tailoring those standards to specific patients requires more investigation. “That’s the next step,” says Dr. Hannon.

“The long-term goal is to create individualized opioid prescriptions based on patient factors, the type of surgery they had, their risk for prolonged opioid use and whether they’ve had opioids for previous surgeries,” he adds.

Dr. Hannon envisions scenarios where a doctor can, based on that personal information and other factors such as the patient’s pain perception, be much more precise and about opioid prescriptions.

Dr. Brummett believes opioid-related patient prescreening and opioid-sparing regimens like Enhanced Recovery After Surgery (ERAS) aren’t pervasive right now. “I don’t think anyone is doing this really well,” he says. “Finding non-stigmatizing ways to screen patients efficiently is not a simple thing to do.”

He advises to watch for certain factors associated with new persistent use of opioids: anxiety, depression, sleep disorders, chronic pain conditions, history of abuse of alcohol and other substances, and tobacco use. Another important factor: remote opioid use. “We often know a person isn’t using opioids, but we don’t know if they’ve used them previously for a prolonged period of time,” he says. “If they have, there’s a better chance they will abuse opioids than would an opioid-naïve patient.

Indeed, it’s vital to delineate the patient’s risk factors associated with dependence. “The No. 1 predictor of post-operative opioid use is pre-operative opioid use,” says Dr. Hannon.

‘A long way to go’

HEALTHY AND HAPP\Y
Margaret Sherman, RN
HEALTHY AND HAPPY Research shows patients who are prescribed fewer opioids don't feel significantly more pain or are any less satisfied with the care they receive.

Researchers, physicians, professional societies and governmental agencies are just several of the many parties looking to curb access to opioids by standardizing prescriptions. The overprescribing problem touches almost every surgical discipline, according to Dr. Brummett, who notes orthopods and otolaryngologists are particularly lagging in addressing this issue, while general surgeons and urologists are ahead of the curve. He believes the key to addressing the problem lies in shared leverage of evidence-based data.

For example, Michigan OPEN’s prescribing recommendations are available online for use (michigan-open.org/prescribing-recommendations). “When I hear groups say they’re going to create prescribing recommendations for surgeries for which we already have a couple years’ worth of data, I think that’s a missed opportunity,” says Dr. Brummett.

“Somebody’s going to put a lot of time, energy and effort into that. I’d rather see them take all that effort and energy and put it toward implementation or other positive change rather than simply recreating what we’ve already done.”

The challenge of relieving a patient’s post-operative pain by reducing or even eliminating opioids from their regimen isn’t an easy task, but the effort to standardize opioids prescriptions based on procedure type has game-changing potential for public health. It’s taking a while, but the movement is starting to gain traction.

“Overprescribing is less of a problem than it once was,” says Dr. Brummett. “But we still have a long way to go.” OSM

Individualized regimens

While much work has been put into standardizing prescriptions based on procedure type, there’s a complementary factor that still needs work: tailoring opioid prescriptions not only to procedures, but also to individual patients. “We need to learn a little bit more about which patients are going to require more pills than others,” says Dr. Hannon.

Becoming a new persistent opioid user is one of the most common complications after elective surgery.
— Chad Brummett, MD

Standardizing prescriptions by procedure type makes things a lot easier from an administrative point of view, but tailoring those standards to specific patients requires more investigation. “That’s the next step,” says Dr. Hannon.

“The long-term goal is to create individualized opioid prescriptions based on patient factors, the type of surgery they had, their risk for prolonged opioid use and whether they’ve had opioids for previous surgeries,” he adds.

Dr. Hannon envisions scenarios where a doctor can, based on that personal information and other factors such as the patient’s pain perception, be much more precise and about opioid prescriptions.

Dr. Brummett believes opioid-related patient prescreening and opioid-sparing regimens like Enhanced Recovery After Surgery (ERAS) aren’t pervasive right now. “I don’t think anyone is doing this really well,” he says. “Finding non-stigmatizing ways to screen patients efficiently is not a simple thing to do.”

He advises to watch for certain factors associated with new persistent use of opioids: anxiety, depression, sleep disorders, chronic pain conditions, history of abuse of alcohol and other substances, and tobacco use. Another important factor: remote opioid use. “We often know a person isn’t using opioids, but we don’t know if they’ve used them previously for a prolonged period of time,” he says. “If they have, there’s a better chance they will abuse opioids than would an opioid-naïve patient.

Indeed, it’s vital to delineate the patient’s risk factors associated with dependence. “The No. 1 predictor of post-operative opioid use is pre-operative opioid use,” says Dr. Hannon.

‘A long way to go’
HEALTHY AND HAPPY Research shows patients who are prescribed fewer opioids don't feel significantly more pain or are any less satisfied with the care they receive.   |  Margaret Sherman, RN

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